1859102-62-7

1859102-62-7 structure
1859102-62-7 structure
  • Name: Mito-TRFS
  • Chemical Name: Mito-TRFS
  • CAS Number: 1859102-62-7
  • Molecular Formula: C38H34IN2O5PS2
  • Molecular Weight: 820.70
  • Catalog: Signaling Pathways Others Others
  • Create Date: 2021-09-12 15:54:56
  • Modify Date: 2024-01-14 12:14:51
  • Mito-TRFS, the first off-on probe, is used to image the mitochondrial thioredoxin reductase (TrxR2) in live cells[1].

Name Mito-TRFS
Description Mito-TRFS, the first off-on probe, is used to image the mitochondrial thioredoxin reductase (TrxR2) in live cells[1].
Related Catalog
In Vitro Mito-TRFS (10 μM) has the maximal absorption at ~375 nm in TE buffer (50 mM Tris-HCl and 1 mM EDTA, pH 7.4) at 37 °C[1]. Mito-TRFS itself has a strong emission at ~480 nm when excited at 375 nm in TE buffer (φ=0.34), but has weak emission when excited at 438 nm[1]. Immunofluorescence[1]. Cell Line: HeLa cells. Concentration: 1 μM. Incubation Time: 2 h. Result: Mito-TRFS is localized predominantly in the mitochondria of live cells.
References

[1]. Yaping Liu, et al. A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model. Chem Commun (Camb). 2016 Feb 7;52(11):2296-9.

Molecular Formula C38H34IN2O5PS2
Molecular Weight 820.70
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