2226742-61-4
2226742-61-4 structure
- Name: CJ-2360
- Chemical Name: CJ-2360
- CAS Number: 2226742-61-4
- Molecular Formula: C27H30FN5O2
- Molecular Weight: 475.56
- Create Date: 2021-09-12 17:45:49
- Modify Date: 2024-01-11 18:55:25
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CJ-2360 is a potent and orally active ALK with IC50s of 2.2, 4.0, 8.8, 6.3, and 8.9 nM against wild-type ALK and F1197M, G1269A, L1196M, and S1206Y ALK mutants, respectively. CJ-2360 displays potenty activity against two clinically reported ALK mutants (C1156Y and L1196M) and a few other kinases (LTK, MERTK, CLK1, DAPK1, and DAPK2) among the 468 kinases evaluated.
| Name | CJ-2360 |
|---|
| Description | CJ-2360 is a potent and orally active ALK with IC50s of 2.2, 4.0, 8.8, 6.3, and 8.9 nM against wild-type ALK and F1197M, G1269A, L1196M, and S1206Y ALK mutants, respectively. CJ-2360 displays potenty activity against two clinically reported ALK mutants (C1156Y and L1196M) and a few other kinases (LTK, MERTK, CLK1, DAPK1, and DAPK2) among the 468 kinases evaluated. |
|---|
| Molecular Formula | C27H30FN5O2 |
|---|---|
| Molecular Weight | 475.56 |