Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: CY 208-243
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Contact: Ms Wang

100999-26-6

100999-26-6 structure

100999-26-6 structure

Name: CY 208-243
Chemical Name: CY 208-243,(-)-(6aR,12bR)-4,6,6a,7,8,12b-Hexahydro-7-methylindolo[4,3-a]phenanthridin
CAS Number: 100999-26-6
Molecular Formula: C₁₉H₁₈N₂
Molecular Weight: 274.36000
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2019-06-09 13:06:27
Modify Date: 2024-01-14 10:23:47
CY 208-243 is a selective dopamine D1 receptor agonist which exhibits antiparkinsonian activity[1].

Name	CY 208-243,(-)-(6aR,12bR)-4,6,6a,7,8,12b-Hexahydro-7-methylindolo[4,3-a]phenanthridin
Synonyms	SynaptoRedTM C2

Description	CY 208-243 is a selective dopamine D1 receptor agonist which exhibits antiparkinsonian activity[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	dopamine D1 receptor[1]
In Vivo	Pretreatment with CY 208-243 (2.5 mg/kg; s.c.) prevents the increase of DA release and metabolism induced by the D-1 antagonist, SCH 23390 (0.05 mg/kg; s.c.)[1]. Animal Model: Male Sprague-Dawley rats (180-200 g)[1] Dosage: 2.5 mg/kg Administration: Subcutaneous Result: Prevented the increase of DA release and metabolism induced by the D-1 antagonist.
References	[1]. Imperato A, et al. CY 208-243, a novel dopamine D-1 receptor agonist, fails to modify dopamine release in freely moving rats. Eur J Pharmacol. 1989 Jan 24;160(1):155-8. [2]. Temlett JA, et al. The D-1 dopamine receptor partial agonist, CY 208-243, exhibits antiparkinsonian activity in the MPTP-treated marmoset. Eur J Pharmacol. 1988 Nov 1;156(2):197-206.

Density	1.225 g/cm3
Boiling Point	466.5ºC at 760 mmHg
Melting Point	227-228ºC
Molecular Formula	C₁₉H₁₈N₂
Molecular Weight	274.36000
Flash Point	236ºC
Exact Mass	274.14700
PSA	19.03000
LogP	3.60780
Vapour Pressure	7.02E-09mmHg at 25°C
Index of Refraction	1.697

Precursor 1
100999-27-7
DownStream 0