149184-22-5

149184-22-5 structure

Name: CGP 55845 hydrochloride
Chemical Name: CGP 55845 hydrochloride,(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinicacidhydrochloride
CAS Number: 149184-22-5
Molecular Formula: C₁₈H₂₂Cl₂NO₃P
Molecular Weight: 402.25200
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2016-04-16 21:14:35
Modify Date: 2024-01-08 21:28:55
CGP55845 hydrochloride is a potent and selective GABAB receptor antagonist with an IC50 of 6 nM. CGP55845 hydrochloride can be used for neurological research[1][2].

Name	CGP 55845 hydrochloride,(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinicacidhydrochloride
Synonyms	CGP 55845 hydrochloride

Description	CGP55845 hydrochloride is a potent and selective GABAB receptor antagonist with an IC50 of 6 nM. CGP55845 hydrochloride can be used for neurological research[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vitro	In the mouse visual cortex, CGP 55845 hydrochloride (1 μM) increases the frequency of spontaneous Ca2+ transients and spontaneous and miniature IPSCs (mIPSCs) but does not affect mIPSC amplitudes or kinetics. CGP55845 hydrochloride significantly increases evoked IPSC (eIPSC) amplitudes and decreases the paired-pulse ratio (PPR)[3].
In Vivo	CGP55845 hydrochloride (i.p.; once; 0.5 mg/kg) treatment increases the number of PSD95 positive puncta as well as density and maturation of dendritic spines in the perirhinal cortex (PRC), and restores novel object recognition (NOR) memory in Cdkl5 KO mice[1]. Animal Model: Cdkl5 +/Y and Cdkl5 -/Y male mice (2-month-old)[1] Dosage: 0.5 mg/kg Administration: i.p.; once Result: Altered NOR recognition memory in Cdkl5 -/Y mice
References	[1]. Laura Gennaccaro, et al. A GABA B receptor antagonist rescues functional and structural impairments in the perirhinal cortex of a mouse model of CDKL5 deficiency disorder. Neurobiol Dis. 2021 Jun;153:105304. [2]. Claire-Marie Vacher, et al. GABA(B) receptors as potential therapeutic targets. Curr Drug Targets CNS Neurol Disord. 2003 Aug;2(4):248-59. [3]. Knut Kirmse, et al. Ambient GABA constrains the strength of GABAergic synapses at Cajal-Retzius cells in the developing visual cortex. J Neurosci. 2006 Apr 19;26(16):4216-27.

Density	1.332g/cm3
Boiling Point	647.9ºC at 760 mmHg
Molecular Formula	C₁₈H₂₂Cl₂NO₃P
Molecular Weight	402.25200
Flash Point	345.6ºC
Exact Mass	401.07100
PSA	79.37000
LogP	4.86640
Vapour Pressure	1.14E-17mmHg at 25°C
Index of Refraction	1.591

RIDADR	NONH for all modes of transport
RTECS	SZ4680000

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