55601-63-3

55601-63-3 structure

Name: uperolein
Chemical Name: 5-Oxoprolylprolyl-α-aspartylprolylasparaginylalanylphenylalanyltyrosylglycylleucylmethioninamide
CAS Number: 55601-63-3
Molecular Formula: C₅₇H₇₉N₁₃O₁₆S
Molecular Weight: 1234.380
Catalog: Research Areas Neurological Disease
Create Date: 2021-09-09 21:05:02
Modify Date: 2024-09-23 09:29:55
Uperolein is a physalaemin-like endecapeptide, produced in the skin of Uperoleia rugosa and Uperoleia marmorata. Uperolein has a spasmodic effect on both the gastrointestinal tract and longitudinal muscles[1][2][3].

Name	5-Oxoprolylprolyl-α-aspartylprolylasparaginylalanylphenylalanyltyrosylglycylleucylmethioninamide
Synonyms	Methioninamide, 5-oxoprolylprolyl-α-aspartylprolylasparaginylalanylphenylalanyltyrosylglycylleucyl- 5-Oxoprolylprolyl-α-aspartylprolylasparaginylalanylphenylalanyltyrosylglycylleucylmethioninamide

Description	Uperolein is a physalaemin-like endecapeptide, produced in the skin of Uperoleia rugosa and Uperoleia marmorata. Uperolein has a spasmodic effect on both the gastrointestinal tract and longitudinal muscles[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Uperolein (10-100 ng/mL) is a tachykinin analogue, causes or reinforces rhythmic movements and increases the tone in isolated circular and longitudinal muscle of the human gastrointestinal tract from the stomach to the colon[2].
In Vivo	Uperolein (0.1 μg/kg and 5 μg/kg; i.v.; single dose) exhibits stimulation activity on the stomach of the anesthetized rat, displays a noticeable spasmogenic activity on the whole stomach from the fundus to the pylorus[3].
References	[1]. Poulter L, et al. Levitide, a neurohormone-like peptide from the skin of Xenopus laevis. Peptide and peptide precursor cDNA sequences. J Biol Chem. 1988 Mar 5;263(7):3279-83. [2]. Anastasi A, et al. Structure of uperolein, a physalaemin-like endecapeptide occurring in the skin of Uperoleia rugosa and Uperoleia marmorata. Experientia. 1975 Apr 15;31(4):394-5. [3]. Zappia L, et al. Effects of natural analogues of substance P on the motility of human gastrointestinal tract in vitro. J Pharm Pharmacol. 1978 Sep;30(9):593-4. [4]. Bertaccini G, et al. Action of some natural peptides on the stomach of the anaesthetized rat. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):163-6.