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Product Name: Itazigrel
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70529-35-0

70529-35-0 structure

Name: Itazigrel
Chemical Name: 4,5-bis(4-methoxyphenyl)-2-(trifluoromethyl)-1,3-thiazole
CAS Number: 70529-35-0
Molecular Formula: C₁₈H₁₄F₃NO₂S
Molecular Weight: 365.36900
Create Date: 2018-08-04 09:22:48
Modify Date: 2024-01-03 11:34:40

Name	4,5-bis(4-methoxyphenyl)-2-(trifluoromethyl)-1,3-thiazole
Synonyms	4,5-bis(p-Methoxyphenyl)-2-(trifluoromethyl)thiazole 2-Trifluormethyl-4,5-bis(p-methoxyphenyl)thiazole Itazigrelum [Latin] Itazogrel ITAZIGREL 4,5-bis-(4-methoxy-phenyl)-2-trifluoromethyl-thiazole 2-Trifluormethyl-4,5-di-p-anisylthiazol

Density	1.285g/cm3
Boiling Point	400.3ºC at 760 mmHg
Molecular Formula	C₁₈H₁₄F₃NO₂S
Molecular Weight	365.36900
Flash Point	195.9ºC
Exact Mass	365.07000
PSA	59.59000
LogP	5.51310
Index of Refraction	1.547

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XJ2983000

CHEMICAL NAME :: Thiazole, 4,5-bis(4-methoxyphenyl)-2-trifluoromethyl-

CAS REGISTRY NUMBER :: 70529-35-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H14-F3-N-O2-S

MOLECULAR WEIGHT :: 365.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4659726

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THHADQ Thrombosis and Haemostasis. (F.K. Schattauer Verlag, Postfach 104545, D-70040 Stuttgart, Germany) V.35- 1976- Volume(issue)/page/year: 46,26,1981

27895-95-0

421-52-3

70529-35-0

Literature: Rynbrandt, Ronald H.; Nishizawa, Edward E.; Balogoyen, Doris P.; Mendoza, A. Rene; Annis, Kathleen A. Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1507 - 1510

15857-57-5

354-38-1

~34%

70529-35-0

Literature: Rynbrandt, R. H.; Nishizawa, E.- E.; Balogoyen, D. P.; Mendoza, A. R.; Annis, U. A. J. Med. Chem., 1981 , vol. 24, p. 1507 - 1510 View citing articles Show Details Gmelin Handbook: F: PerFHalOrg.SVol.1, 6.2.1.2, page 193 - 198 Show Details The Upjohn Co., Rynbrandt, R. H. Patent: DE2836742 , 1979 ; C.A., 1979 , vol. 91, p. 20490

Precursor 3
27895-95-0 421-52-3 354-38-1
DownStream 0

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