1854034-70-0

1854034-70-0 structure

Name: Bis-sulfone-PEG4-DBCO
Chemical Name: Bis-sulfone-PEG4-DBCO
CAS Number: 1854034-70-0
Molecular Formula: C₅₄H₅₉N₃O₁₂S₂
Molecular Weight: 1006.19
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2021-09-10 16:49:07
Modify Date: 2024-01-07 00:36:13
Bis-sulfone-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Bis-sulfone-PEG4-DBCO

Description	Bis-sulfone-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1014.