Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Antitumor agent-28
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2097499-67-5

2097499-67-5 structure

2097499-67-5 structure

Name: Antitumor agent-28
Chemical Name: Antitumor agent-28
CAS Number: 2097499-67-5
Molecular Formula: C₂₅H₃₂N₆O₄S
Molecular Weight: 512.62
Catalog: Signaling Pathways Cell Cycle/DNA Damage ATM/ATR
Create Date: 2021-09-05 18:33:55
Modify Date: 2024-01-06 16:33:40
Antitumor agent-28 selectively inhibits ataxia telangiectasia mutated (ATM) kinase. Antitumor agent-28 prevents ATM mediated disease and has potent anti-cancer activity[1].

Name	Antitumor agent-28

Description	Antitumor agent-28 selectively inhibits ataxia telangiectasia mutated (ATM) kinase. Antitumor agent-28 prevents ATM mediated disease and has potent anti-cancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> ATM/ATR Signaling Pathways >> PI3K/Akt/mTOR >> ATM/ATR
Target	ATM ATR
In Vitro	Antitumor agent-28 inhibits ataxia telangiectasia mutated (ATM; IC50=7.6 nM; HT29 cells), ataxia telangiectasia and Rad3-related protein (ATR; IC50=18 μM; HT29 cells), PI3Ka (IC50=0.24 μM; BT474 cells). Antitumor agent-28 does not inhibit mTOR in MDA-MB-468 cells[1].
References	[1]. Kurt Gordon Pike, et al. Composés imidazo[4,5c]quinoline-2-one et leur utilisation dans le traitement du cancer. WO2017076898A1.

Molecular Formula	C₂₅H₃₂N₆O₄S
Molecular Weight	512.62

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