1919828-81-1
1919828-81-1 structure
- Name: DDX3-IN-2
- Chemical Name: DDX3-IN-2
- CAS Number: 1919828-81-1
- Molecular Formula: C20H23N5O
- Molecular Weight: 349.43
- Catalog: Signaling Pathways Anti-infection HIV
- Create Date: 2021-09-09 11:31:12
- Modify Date: 2024-01-31 09:20:27
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DDX3-IN-2 is an active DEADbox polypeptide 3 (DDX3) inhibitor with an IC50 value of 0.3 μM. DDX3-IN-2 shows a broad spectrum of antiviral activity. DDX3-IN-2 has the potential to overcome HIV resistance[1].
| Name | DDX3-IN-2 |
|---|
| Description | DDX3-IN-2 is an active DEADbox polypeptide 3 (DDX3) inhibitor with an IC50 value of 0.3 μM. DDX3-IN-2 shows a broad spectrum of antiviral activity. DDX3-IN-2 has the potential to overcome HIV resistance[1]. |
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| Related Catalog | |
| Target |
HIV |
| In Vitro | DDX3-IN-2 behaves as a competitive inhibitor with respect to the RNA substrate, which can be seen by the decrease in its inhibition potency as a function of increasing RNA substrate concentrations. DDX3-IN-2 is found to be completely inactive against the ATPase of DDX3, DDX1 helicase, and DENV NS3 helicase[1]. |
| In Vivo | DDX3-IN-2 (20 mg/kg; tail vein injection) possesses excellent biocompatibility, and Wistar rats shows a good tolerance to the dose of 20 mg/kg[1]. DDX3-IN-2 (10 mg/kg; i.v. bolus injection; 0~25 hours) rapidly eliminates the half-life elimination and the plasmatic clearance values[1]. Animal Model: Wistar rats[1] Dosage: Tail vein injection Administration: 20 mg/kg Result: Possessed excellent biocompatibility, and Wistar rats showed a good tolerance to the dose of 20 mg/kg. Animal Model: Rats[1] Dosage: I.v. bolus injection (Pharmacokinetic Analysis) Administration: 10 mg/kg; 0~25 hours Result: Rapidly eliminated the half-life elimination and the plasmatic clearance values. |
| References |
| Molecular Formula | C20H23N5O |
|---|---|
| Molecular Weight | 349.43 |