1366233-41-1
1366233-41-1 structure
- Name: GSK2332255B
- Chemical Name: GSK2332255B
- CAS Number: 1366233-41-1
- Molecular Formula: C18H19ClFN3O3S
- Molecular Weight: 411.88
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
- Create Date: 2021-10-23 21:05:53
- Modify Date: 2024-01-04 16:38:45
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GSK2332255B is a potent, selective TRPC3 and TRPC6 antagonist with IC50s of 5 nM and 4 nM for rat TRPC3 and rat TRPC6. GSK2332255B shows ≥100-fold selectivity for TRPC3/6 over other calcium-permeable channels[1].
| Name | GSK2332255B |
|---|
| Description | GSK2332255B is a potent, selective TRPC3 and TRPC6 antagonist with IC50s of 5 nM and 4 nM for rat TRPC3 and rat TRPC6. GSK2332255B shows ≥100-fold selectivity for TRPC3/6 over other calcium-permeable channels[1]. |
|---|---|
| Related Catalog | |
| Target |
rTRPC3:5 nM (IC50) rTRPC6:4 nM (IC50) |
| In Vitro | Nuclear factor of activated T cells (NFAT) activation by Ang II ( angiotensin II) is blocked in a dose dependent manner by GSK255B (0.01, 0.1, and 1 μM) in HEK293T cells overexpressing TRPC3. GSK255B blocks NFAT activation by Ang II in HEK293T cells expressing a mutant TRPC6 channel with T70 and S322 mutated to glutamic acid (SETE)[1]. GSK255B (10 μM) blocks calcium entry stimulated by Phenylephrine (20 μM) in rat neonatal cardiac myocytes. GSK255B dose-dependent blockade of cell hypertrophy signaling triggered by angiotensin II or endothelin-1 in HEK293T cells as well as in neonatal and adult cardiac myocytes[1]. |
| References |
| Molecular Formula | C18H19ClFN3O3S |
|---|---|
| Molecular Weight | 411.88 |