105250-85-9
105250-85-9 structure
- Name: Osteogenic Growth Peptide (10-14) trifluoroacetate salt
- Chemical Name: Osteogenic Growth Peptide (10-14)
- CAS Number: 105250-85-9
- Molecular Formula: C24H29N5O7
- Molecular Weight: 499.51600
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Src
- Create Date: 2017-01-13 14:52:15
- Modify Date: 2024-01-02 19:35:01
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Osteogenic Growth Peptide (10-14) (OGP(10-14)), the C-terminal truncated pentapeptide of osteogenic growth peptide (OGP), retains the full OGP-like activity. Osteogenic Growth Peptide (10-14) is responsible for the binding to the OGP receptor and activates an intracellular Gi-protein-MAP kinase signaling pathway. Osteogenic Growth Peptide (10-14) is a potent mitogen and stimulator of osteogenesis and hematopoiesis. Osteogenic Growth Peptide (10-14) acts as a Src inhibitor[1][2][3][4].
| Name | Osteogenic Growth Peptide (10-14) |
|---|---|
| Synonyms |
Tyr-Gly-Phe-Gly-gly
Glycine,N-(N-(N-(N-L-tyrosylglycyl)-L-phenylalanyl)glycyl) H-TYR-GLY-PHE-GLY-GLY-OH historphin Tyrosyl-glycyl-phenylalanyl-glycyl-glycine OGP (10-14) |
| Description | Osteogenic Growth Peptide (10-14) (OGP(10-14)), the C-terminal truncated pentapeptide of osteogenic growth peptide (OGP), retains the full OGP-like activity. Osteogenic Growth Peptide (10-14) is responsible for the binding to the OGP receptor and activates an intracellular Gi-protein-MAP kinase signaling pathway. Osteogenic Growth Peptide (10-14) is a potent mitogen and stimulator of osteogenesis and hematopoiesis. Osteogenic Growth Peptide (10-14) acts as a Src inhibitor[1][2][3][4]. |
|---|---|
| Related Catalog | |
| In Vitro | Osteogenic Growth Peptide (10-14) (OGP(10-14)) induces proliferation and differentiation in fibroblast and osteoblast cell lines[3]. Osteogenic Growth Peptide (10-14) induces TPO-primed M07-e cells differentiation through RhoA/TGFβ1/SFKs signalling pathway. In particular Historphin acts as a Src inhibitor, showing the same effects of PP2[4]. |
| In Vivo | Osteogenic Growth Peptide (10-14) (OGP(10-14)) increases bone formation and trabecular bone density and stimulates fracture healing when administered to mice and rats[1]. |
| References |
| Density | 1.352g/cm3 |
|---|---|
| Boiling Point | 1028ºC at 760mmHg |
| Molecular Formula | C24H29N5O7 |
| Molecular Weight | 499.51600 |
| Flash Point | 575.5ºC |
| Exact Mass | 499.20700 |
| PSA | 199.95000 |
| LogP | 0.68660 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.609 |