736183-35-0

736183-35-0 structure

Name: BGC-20-1531 free base
Chemical Name: BGC-20-1531 free base
CAS Number: 736183-35-0
Molecular Formula: C₂₆H₂₄N₂O₆S
Molecular Weight: 492.54
Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
Create Date: 2021-11-12 11:53:48
Modify Date: 2024-01-04 19:10:59
BGC-20-1531 (PGN 1531) free base is a potent and selective prostanoid EP4 receptor antagonist, with a pKb of 7.6. BGC-20-1531 free base has the potential for the research of migraine headache[1].

Name	BGC-20-1531 free base

Description	BGC-20-1531 (PGN 1531) free base is a potent and selective prostanoid EP4 receptor antagonist, with a pKb of 7.6. BGC-20-1531 free base has the potential for the research of migraine headache[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Neurological Disease
Target	EP4:3 nM (Ki)
In Vitro	BGC-20-1531 free base competitively antagonized PGE2-induced vasodilatation of human middle cerebral (pKb = 7.8) and meningeal (pKb = 7.6; Ki = 3 nM) arteries, but had no effect on responses induced by PGE2 on coronary, pulmonary or renal arteries[1].
In Vivo	BGC-20-1531 free base (1-10 mg/kg; i.v.) causes a dose-dependent antagonism of the PGE2-induced increase in canine carotid blood flow[1]. Animal Model: Beagle dogs[1] Dosage: 1-10 mg/kg Administration: I.v. Result: Caused a dose-dependent antagonism of the PGE2-induced increase in canine carotid blood flow.
References	[1]. Maubach KA, et al. BGC20-1531, a novel, potent and selective prostanoid EP receptor antagonist: a putative new treatment for migraine headache. Br J Pharmacol. 2009;156(2):316-327.

Molecular Formula	C₂₆H₂₄N₂O₆S
Molecular Weight	492.54