1001264-73-8

1001264-73-8 structure

Name: Ipatasertib-NH2 dihydrochloride
Chemical Name: Ipatasertib-NH2 dihydrochloride
CAS Number: 1001264-73-8
Molecular Formula: C₂₁H₂₈Cl₃N₅O₂
Molecular Weight: 488.84
Catalog: Research Areas Cancer
Create Date: 2021-10-11 00:38:08
Modify Date: 2024-06-21 17:55:08
Ipatasertib-NH2 dihydrochloride is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase[1].

Name	Ipatasertib-NH2 dihydrochloride

Description	Ipatasertib-NH2 dihydrochloride is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase[1].
Related Catalog	Research Areas >> Cancer
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. You I, et al. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 Jan 16;27(1):66-73.e7.