2226552-64-1

2226552-64-1 structure
2226552-64-1 structure
  • Name: WSD0922
  • Chemical Name: WSD0922
  • CAS Number: 2226552-64-1
  • Molecular Formula: C23H21F3N4O2
  • Molecular Weight: 442.43
  • Catalog: Signaling Pathways JAK/STAT Signaling EGFR
  • Create Date: 2021-11-02 17:48:01
  • Modify Date: 2025-08-25 09:52:57
  • WSD-0922 is a potent, selective, orally active, and BBB penetrable EGFR/EGFRVIII inhibitor. WSD-0922 is against EGFRm+ (EGFRvIII/Del19/L858R) with an IC50 of <10 nM. WSD0922 shows good safety profile and preclinical anti-tumor efficacy[1].

Name WSD0922
Description WSD-0922 is a potent, selective, orally active, and BBB penetrable EGFR/EGFRVIII inhibitor. WSD-0922 is against EGFRm+ (EGFRvIII/Del19/L858R) with an IC50 of <10 nM. WSD0922 shows good safety profile and preclinical anti-tumor efficacy[1].
Related Catalog
Target

IC50: EGFRm+ (EGFRvIII/Del19/L858R)[1]

In Vivo WSD0922 treatment results in tumor regression on cetuximab resistant PDX model of HNSCC. WSD0922 demonstrates remarkable tumor regression in 3 PDX models (platinum sensitive/insensitive/EGFRm+). WSD0922 is well tolerated in GLP tox at dose ~10x clinical equivalent dose.[1]
References

[1]. Wei Zhong, et al. Abstract 1326: WSD0922: A BBB penetrable EGFR/EGFRVIII inhibitor for the treatment of GBM and metastatic CNS tumor. Experimental and Molecular Therapeutics.

Molecular Formula C23H21F3N4O2
Molecular Weight 442.43
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