Name | 6-(4-(4-Methylthiazol-2-yl)-1H-imidazol-5-yl)benzo[d]thiazole hydrochloride |
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Synonyms |
Benzothiazole, 6-[4-(4-methyl-2-thiazolyl)-1H-imidazol-5-yl]-, hydrochloride (1:1)
6-[4-(4-Methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole hydrochloride (1:1) MFCD32633583 |
Description | TP0427736 hydrochloride is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50=836 nM). TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. TP0427736 hydrochloride can be used for the research of androgenic alopecia (AGA)[1]. |
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Related Catalog | |
References |
Molecular Formula | C14H11ClN4S2 |
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Molecular Weight | 334.847 |
Exact Mass | 334.011353 |