1375073-93-0

1375073-93-0 structure

Name: Exaluren
Chemical Name: NB124
CAS Number: 1375073-93-0
Molecular Formula: C₁₉H₃₈N₄O₁₀
Molecular Weight: 482.53
Catalog: Research Areas Others
Create Date: 2022-01-04 21:45:52
Modify Date: 2023-01-14 12:21:05
Exaluren (ELX-02) is an synthetic eukaryotic ribosome-selective glycoside that induces read through of nonsense mutations, resulting in normally localized full-length functional proteins. Exaluren is used for the research of cystic fibrosis caused by nonsense mutations[1].

Name	NB124
Synonyms	D-glycero-α-D-gluco-Heptopyranoside, (1R,2R,3S,4R,6S)-4,6-diamino-2-[(5-amino-5,6-dideoxy-α-L-talofuranosyl)oxy]-3-hydroxycyclohexyl 2-amino-2,7-dideoxy- NB124 (1R,2R,3S,5R,6S)-3,5-Diamino-2-({(5R)-2-amino-2-deoxy-5-[(1R)-1-hydroxyethyl]-α-D-xylopyranosyl}oxy)-6-hydroxycyclohexyl 5-amino-5,6-dideoxy-α-L-talofuranoside

Description	Exaluren (ELX-02) is an synthetic eukaryotic ribosome-selective glycoside that induces read through of nonsense mutations, resulting in normally localized full-length functional proteins. Exaluren is used for the research of cystic fibrosis caused by nonsense mutations[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Leubitz A, Frydman-Marom A, Sharpe N, van Duzer J, Campbell KCM, Vanhoutte F. Safety, Tolerability, and Pharmacokinetics of Single Ascending Doses of ELX-02, a Potential Treatment for Genetic Disorders Caused by Nonsense Mutations, in Healthy Volunteers. Clin Pharmacol Drug Dev. 2019 Nov;8(8):984-994.