1425511-32-5

1425511-32-5 structure

Name: Luvadaxistat
Chemical Name: 4-Hydroxy-6-{2-[4-(trifluoromethyl)phenyl]ethyl}-3(2H)-pyridazinone
CAS Number: 1425511-32-5
Molecular Formula: C₁₃H₁₁F₃N₂O₂
Molecular Weight: 284.23
Catalog: Research Areas Others
Create Date: 2021-12-28 20:36:00
Modify Date: 2024-01-24 10:21:50
TAK-831 is a highly selective and potent inhibitor of D-amino acid oxidase (DAAO) and can be used in studies of schizophrenia[1][2].

Name	4-Hydroxy-6-{2-[4-(trifluoromethyl)phenyl]ethyl}-3(2H)-pyridazinone
Synonyms	4-Hydroxy-6-{2-[4-(trifluoromethyl)phenyl]ethyl}-3(2H)-pyridazinone 3(2H)-Pyridazinone, 4-hydroxy-6-[2-[4-(trifluoromethyl)phenyl]ethyl]-

Description	TAK-831 is a highly selective and potent inhibitor of D-amino acid oxidase (DAAO) and can be used in studies of schizophrenia[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Wang H, Norton J, Xu L, DeMartinis N, Sen R, Shah A, Farmer J, Lynch D. Results of a randomized double-blind study evaluating luvadaxistat in adults with Friedreich ataxia. Ann Clin Transl Neurol. 2021 Jun;8(6):1343-1352. [2]. Yoneyama T, Sato S, Sykes A, Fradley R, Stafford S, Bechar S, Howley E, Patel T, Tagawa Y, Moriwaki T, Asahi S. Mechanistic Multilayer Quantitative Model for Nonlinear Pharmacokinetics, Target Occupancy and Pharmacodynamics (PK/TO/PD) Relationship of D-Amino Acid Oxidase Inhibitor, TAK-831 in Mice. Pharm Res. 2020 Aug 5;37(8):164.