80685-22-9

80685-22-9 structure

Name: 9-Carboxymethoxymethylguanine
Chemical Name: 9-Carboxymethoxymethylguanine
CAS Number: 80685-22-9
Molecular Formula: C₈H₉N₅O₄
Molecular Weight: 239.19
Catalog: Signaling Pathways Anti-infection HSV
Create Date: 2022-01-05 16:53:05
Modify Date: 2025-08-24 23:54:23
9-Carboxymethoxymethylguanine is the main metabolite of Aciclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent[1].

Name	9-Carboxymethoxymethylguanine
Synonyms	Acetic acid, 2-[(2-amino-3,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]- N28227W35C [(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy]acetic acid CMMG 9-Carboxymethoxymethylguanine

Description	9-Carboxymethoxymethylguanine is the main metabolite of Aciclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection
In Vitro	Acyclovir is metabolized by the alcohol dehydrogenase (ADH) enzyme to Acyclovir aldehyde, and acyclovir aldehyde is subsequently metabolized by the aldehyde dehydrogenase (ALDH) enzyme to 9-Carboxymethoxymethylguanine (CMMG)[1].
References	[1]. Patrina Gunness, et al. Acyclovir-induced nephrotoxicity: the role of the acyclovir aldehyde metabolite. Transl Res. 2011 Nov;158(5):290-301.