942518-19-6

942518-19-6 structure

Name: L-Homopropargylglycine hydrochloride
Chemical Name: (2S)-2-Amino-5-hexynoic acid hydrochloride (1:1)
CAS Number: 942518-19-6
Molecular Formula: C₆H₁₀ClNO₂
Molecular Weight: 163.60
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2022-01-14 13:42:42
Modify Date: 2025-08-27 11:04:38
L-Homopropargylglycine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine hydrochloride is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor[1][2].

Name	(2S)-2-Amino-5-hexynoic acid hydrochloride (1:1)
Synonyms	MFCD31619332 (2S)-2-Amino-5-hexynoic acid hydrochloride (1:1) 5-Hexynoic acid, 2-amino-, (2S)-, hydrochloride (1:1)

Description	L-Homopropargylglycine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine hydrochloride is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl-Chain
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018;36:553-562. [2]. Shen Y, et al. Protocol for visualizing newly synthesized proteins in primary mouse hepatocytes. STAR Protoc. 2021;2(3):100616. Published 2021 Jun 17.