2136633-23-1
2136633-23-1 structure
- Name: Disitamab vedotin
- Chemical Name: Disitamab vedotin
- CAS Number: 2136633-23-1
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways JAK/STAT Signaling EGFR
- Create Date: 2022-01-17 19:32:44
- Modify Date: 2024-01-12 12:29:25
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Disitamab vedotin (RC48) is an antibody-drug conjugate (ADC) comprising a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) conjugated via a cleavable linker to the cytotoxic agent monomethyl auristatin E. Disitamab vedotin enhances antitumor immunity[1].
| Name | Disitamab vedotin |
|---|
| Description | Disitamab vedotin (RC48) is an antibody-drug conjugate (ADC) comprising a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) conjugated via a cleavable linker to the cytotoxic agent monomethyl auristatin E. Disitamab vedotin enhances antitumor immunity[1]. |
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| Related Catalog | |
| Target |
HER2 |
| In Vitro | The antibody part was a humanized monoclonal antibody targeting HER2, the small molecule toxin was monomethyl auristatin E (MMAE), a synthetic antineoplastic agent. A protease cleavable linker covalently attached MMAE to the antibody[2]. |
| References |
[1]. Deeks ED. Disitamab Vedotin: First Approval. Drugs. 2021;81(16):1929-1935. |
| No Any Chemical & Physical Properties |