2079939-05-0
2079939-05-0 structure
- Name: Sirpiglenastat
- Chemical Name: Sirpiglenastat
- CAS Number: 2079939-05-0
- Molecular Formula: C22H27N5O5
- Molecular Weight: 441.48
- Catalog: Research Areas Cancer
- Create Date: 2022-01-11 09:42:55
- Modify Date: 2025-08-25 12:37:17
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Sirpiglenastat (DRP-104) is a broad acting glutamine antagonist. Sirpiglenastat has anticancer effects by directly targeting tumor metabolism and simultaneously inducing a potent antitumor immune response[1][2].
| Name | Sirpiglenastat |
|---|
| Description | Sirpiglenastat (DRP-104) is a broad acting glutamine antagonist. Sirpiglenastat has anticancer effects by directly targeting tumor metabolism and simultaneously inducing a potent antitumor immune response[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Sirpiglenastat (DRP-104) treatment shows broad immune cell modulation effects including increased T, NK, and macrophages. Sirpiglenastat decreases pro-tumorigenic cytokines such as VEGF and KC (IL-8)[1]. |
| In Vivo | CT26 bearing mice treated with Sirpiglenastat (DRP-104) (0.5 mg/kg; s.c.; once a day; for 5 days) shows tumor growth inhibition at day 12 of 90%. Median survival days are 36 days[1]. Sirpiglenastat (0.5 mg/kg; s.c) treatment significantly inhibits tumor growth in the H22 model[1]. Animal Model: CT26 bearing mice[1] Dosage: 0.5 mg/kg Administration: s.c.; once a day; for 5 days Result: Showed tumor growth inhibition in mice. |
| References |
| Molecular Formula | C22H27N5O5 |
|---|---|
| Molecular Weight | 441.48 |