2357110-84-8

2357110-84-8 structure

Name: Thalidomide-4-C3-NH2 hydrochloride
Chemical Name: Thalidomide-4-C3-NH2 hydrochloride
CAS Number: 2357110-84-8
Molecular Formula: C₁₆H₁₈ClN₃O₄
Molecular Weight: 351.78
Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
Create Date: 2022-03-21 10:46:19
Modify Date: 2025-08-21 07:32:19
Thalidomide-4-C3-NH2 hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-C3-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1].

Name	Thalidomide-4-C3-NH2 hydrochloride

Description	Thalidomide-4-C3-NH2 hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-C3-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-994.