1517965-94-4
1517965-94-4 structure
- Name: Vornorexant
- Chemical Name: Vornorexant
- CAS Number: 1517965-94-4
- Molecular Formula: C23H22FN7O2
- Molecular Weight: 447.46
- Catalog: Signaling Pathways GPCR/G Protein Orexin Receptor (OX Receptor)
- Create Date: 2021-12-19 23:46:06
- Modify Date: 2025-08-21 15:48:59
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Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC50 values of 1.05 nM and 1.27 nM, respectively. Vornorexant exhibits potent sleep-promoting effects in vivo and can be used for insomnia treatment research[1].
| Name | Vornorexant |
|---|
| Description | Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC50 values of 1.05 nM and 1.27 nM, respectively. Vornorexant exhibits potent sleep-promoting effects in vivo and can be used for insomnia treatment research[1]. |
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| Related Catalog | |
| In Vivo | Vornorexant (oral administration; 1-10 mg/kg) exhibits potent sleep-promoting effects at a po. dose of 1 mg/kg in a rat polysomnogram study. It results in a dose-dependent increase in the percentage of total sleep[1]. Vornorexant exhibits optimal PK properties with a rapid Tmax and short half-lives in rats and dogs. The T1/2 is 0.238 hours and 1.16 hours, respectively in rat and dog[1]. Animal Model: Rat[1] Dosage: 1, 3, 10 mg/kg Administration: Oral administration to rats prior to turning the light off (start of the active phase); 1-10 mg/kg Result: Possessed promising sleep-inducing and sleep-promoting effects. |
| References |
| Molecular Formula | C23H22FN7O2 |
|---|---|
| Molecular Weight | 447.46 |