Shanghai Nianxing Industrial Co., Ltd
China
Product Name: VPC-18005
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2242480-48-2

2242480-48-2 structure

2242480-48-2 structure

Name: VPC-18005
Chemical Name: VPC-18005
CAS Number: 2242480-48-2
Molecular Formula: C₁₅H₁₇N₃O₃S
Molecular Weight: 319.38
Catalog: Research Areas Cancer
Create Date: 2022-01-08 18:02:44
Modify Date: 2024-01-04 17:52:10
VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, and disrupts the ERG binding to DNA. VPC-18005 is a potent inhibitor of luciferase activity[1].

Name	VPC-18005

Description	VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, and disrupts the ERG binding to DNA. VPC-18005 is a potent inhibitor of luciferase activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	VPC-18005 is found to inhibit pETS-luc reporter activity in PNT1B-ERG and VCaP cells with IC50 values of 3 and 6 μM, respectively[1]. VPC-18005 could suppress ERG reporter activity without exhibiting overt cytotoxicity[1]. VPC-18005 inhibits migration and invasion of ERG-overexpressing cells in vitro[1]. VPC-18005 can antagonize the metastatic potential of ERG-expressing prostate cells[1]. The exposure of larvae to 1 or 10 µM of VPC-18005 produced a 20–30% decrease in the dissemination of cancer cells in zebrafsh[2]. Cell Viability Assay[1] Cell Line: PNT1B-Mock cells and PNT1B-ERG cells. Concentration: 5 µM. Incubation Time: 24 h. Result: Inhibited migration and invasion of prostate cell lines in vitro.
References	[1]. Miriam S Butler, et al. Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer. Oncotarget. 2017 Jun 27;8(26):42438-42454. [2]. Haneen Amawi, et al. The use of zebrafish model in prostate cancer therapeutic development and discovery. Cancer Chemother Pharmacol. 2021 Mar;87(3):311-325.

Molecular Formula	C₁₅H₁₇N₃O₃S
Molecular Weight	319.38

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