Shanghai Nianxing Industrial Co., Ltd
China
Product Name: GW284543 hydrochloride
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

179246-08-3

179246-08-3 structure

179246-08-3 structure

Name: GW284543 hydrochloride
Chemical Name: GW 284543 hydrochloride-UNC 10225170 hydrochloride
CAS Number: 179246-08-3
Molecular Formula: C₂₃H₂₁ClN₂O₃
Molecular Weight: 408.88
Catalog: Signaling Pathways MAPK/ERK Pathway MEK
Create Date: 2022-01-07 17:41:48
Modify Date: 2025-08-25 20:48:48
GW284543 (UNC10225170) hydrochloride is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein[1].

Name	GW 284543 hydrochloride-UNC 10225170 hydrochloride

Description	GW284543 (UNC10225170) hydrochloride is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> MEK
Target	MEK5
In Vitro	GW284543 (10 and 20 μM; 6 h) treatment inhibits MEK5 in a dose-dependent manner and reduces pERK5[1]. Western Blot Analysis[1] Cell Line: MIA PaCa-2 cells Concentration: 10 and 20 μM Incubation Time: 6 hours Result: Reduced phosphorylation of ERK5, and decreased endogenous MYC protein.
References	[1]. Vaseva AV, et al. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Cancer Cell. 2018 Nov 12;34(5):807-822.e7.

Molecular Formula	C₂₃H₂₁ClN₂O₃
Molecular Weight	408.88
Storage condition	Sealed in dry,Room Temperature

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