2607138-82-7
2607138-82-7 structure
- Name: ART812
- Chemical Name: ART812
- CAS Number: 2607138-82-7
- Molecular Formula: C19H16ClF4N3O4
- Molecular Weight: 461.79
- Catalog: Research Areas Cancer
- Create Date: 2022-03-03 11:10:57
- Modify Date: 2025-08-25 08:58:53
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ART812 is a DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM. ART812 has an IC50 value of 240 nM for cell based microhomology-mediated end joining (MMEJ)[1][2].
| Name | ART812 |
|---|
| Description | ART812 is a DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM. ART812 has an IC50 value of 240 nM for cell based microhomology-mediated end joining (MMEJ)[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Polθ:7.6 nM (IC50) |
| In Vitro | ART812 (0-40 μM) elicits Polθ inhibitor sensitivity in MDA-MB-436 SHLD2 knockout cells[1]. |
| In Vivo | ART812 (100 mg/kg; p.o. daily for 76 days) shows significant tumour inhibition in rats bearing established MDA-MB-436 BRCA1/SHLD2 defective tumours (volume 250-350 mm3)[1]. |
| References |
| Molecular Formula | C19H16ClF4N3O4 |
|---|---|
| Molecular Weight | 461.79 |