2108567-79-7
2108567-79-7 structure
- Name: (rel)-ML-SI3
- Chemical Name: rel-N-((1R,2R)-2-(4-(2-Methoxyphenyl)piperazin-1-yl)cyclohexyl)benzenesulfonamide
- CAS Number: 2108567-79-7
- Molecular Formula: C23H31N3O3S
- Molecular Weight: 429.58
- Catalog: Signaling Pathways Autophagy Autophagy
- Create Date: 2022-03-03 10:24:50
- Modify Date: 2024-01-07 08:24:20
-
(rel)-ML-SI3 is the isomer of ML-SI3 (HY-139426). ML-SI3 is a TRPML Channel Inhibitor. ML-SI3 blocks TRPML1 and TRPML2 with IC50s of 4.7 μM and 1.7 μM, respectively. ML-SI3 prevents lysosomal calcium efflux and blocks downstream TRPML1-mediated induction of autophagy[1][2].
| Name | rel-N-((1R,2R)-2-(4-(2-Methoxyphenyl)piperazin-1-yl)cyclohexyl)benzenesulfonamide |
|---|---|
| Synonyms | MFCD32690912 |
| Description | (rel)-ML-SI3 is the isomer of ML-SI3 (HY-139426). ML-SI3 is a TRPML Channel Inhibitor. ML-SI3 blocks TRPML1 and TRPML2 with IC50s of 4.7 μM and 1.7 μM, respectively. ML-SI3 prevents lysosomal calcium efflux and blocks downstream TRPML1-mediated induction of autophagy[1][2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 4.7 μM (TRPML1), 1.7 μM (TRPML2)[1] |
| References |
[1]. [2]. |
| Density | 1.26±0.1 g/cm3(Predicted) |
|---|---|
| Boiling Point | 589.3±60.0 °C(Predicted) |
| Molecular Formula | C23H31N3O3S |
| Molecular Weight | 429.58 |