Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Lck Inhibitor III
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1188890-30-3

1188890-30-3 structure

1188890-30-3 structure

Name: Lck Inhibitor III
Chemical Name: Lck Inhibitor III
CAS Number: 1188890-30-3
Molecular Formula: C₂₅H₂₈N₆O₃・H₂O
Molecular Weight: 478.55
Catalog: Signaling Pathways Immunology/Inflammation Interleukin Related
Create Date: 2022-03-28 11:45:20
Modify Date: 2025-09-19 01:22:07
Lck Inhibitor III (compound 12h) is a potent Lck inhibitor, with an IC50 of 867 nM. Lck Inhibitor III inhibits IL-2 synthesis in Jurkat cells, with an IC50 of 1.270 μM[1].

Name	Lck Inhibitor III
Synonyms	2-(1H-Benzo[d]imidazol-1-yl)-N-(5-methoxy-2-methylphenyl)-6-(2-morpholinoethoxy)pyrimidin-4-amine, hydrate

Description	Lck Inhibitor III (compound 12h) is a potent Lck inhibitor, with an IC50 of 867 nM. Lck Inhibitor III inhibits IL-2 synthesis in Jurkat cells, with an IC50 of 1.270 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src
Target	IL-2 Lck:867 nM (IC50)
References	[1]. Sabat M, et al. The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck). Bioorg Med Chem Lett. 2006 Dec 1;16(23):5973-7.

Molecular Formula	C₂₅H₂₈N₆O₃・H₂O
Molecular Weight	478.55
Water Solubility	Soluble in DMSO (100 mg/ml), and ethanol (25 mg/ml).

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