1443748-47-7

1443748-47-7 structure

Name: VU0469650
Chemical Name: VU 0469650 hydrochloride
CAS Number: 1443748-47-7
Molecular Formula: C₂₂H₂₈N₄O
Molecular Weight: 364.48
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2022-03-26 18:15:47
Modify Date: 2024-04-07 15:22:48
VU0469650 is a potent, selective and CNS-penetrated negative allosteric modulator of mGlu1 receptor, with an IC50 of 99 nM[1].

Name	VU 0469650 hydrochloride
Synonyms	3-[(3R)-4-(Adamantan-1-ylcarbonyl)-3-methyl-1-piperazinyl]-2-pyridinecarbonitrile 2-Pyridinecarbonitrile, 3-[(3R)-3-methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]- 3-[(3R)-3-Methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-2-pyridinecarbonitrile hydrochloride

Description	VU0469650 is a potent, selective and CNS-penetrated negative allosteric modulator of mGlu1 receptor, with an IC50 of 99 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	mGluR 1:99 nM (IC50)
In Vivo	VU0469650 (male Sprague-Dawley rats, 0.2 mg/kg, IV, once) exhibits moderate to high clearance, a moderate volume of distribution, and a half-life of approximately 1 hour[1]. VU0469650 (male Sprague-Dawley rats, 10 mg/kg, IP, once) shows an excellent selectivity profile and good exposure in both plasma and brain samples[1].
References	[1]. Lovell KM, Felts AS, Rodriguez AL, et al. N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats. Bioorg Med Chem Lett. 2013;23(13):3713-3718.