2241651-99-8
2241651-99-8 structure
- Name: AZ194
- Chemical Name: CRMP2-Ubc9-NaV1.7 inhibitor 194
- CAS Number: 2241651-99-8
- Molecular Formula: C34H31F2N3O3
- Molecular Weight: 567.62
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
- Create Date: 2022-03-25 10:04:04
- Modify Date: 2025-08-27 12:58:29
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AZ194 is a first-in-class, orally active inhibitor of CRMP2-Ubc9 interaction and inhibitor of NaV1.7 (IC50=1.2 μM). AZ194 blocks SUMOylation of CRMP2 to selectively reduce the amount of surface-expressed NaV1.7. Antinociceptive effects[1].
| Name | CRMP2-Ubc9-NaV1.7 inhibitor 194 |
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| Description | AZ194 is a first-in-class, orally active inhibitor of CRMP2-Ubc9 interaction and inhibitor of NaV1.7 (IC50=1.2 μM). AZ194 blocks SUMOylation of CRMP2 to selectively reduce the amount of surface-expressed NaV1.7. Antinociceptive effects[1]. |
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| Related Catalog | |
| In Vivo | AZ194 would provide pain relief in rat models of chemotherapy- and nerve injury- induced neuropathic pain. AZ194 (orally; at 2 and 10 mg/kg) restores mechanical sensitivity in animals with chemotherapy-induced and nerve injury-induced neuropathic nociception[1]. AZ194 (10 mg/kg; ip; CD1 male mice) does not affect motor performance (open field). AZ194 synergizes with commonly used painkillers, engages NaV1.7-dependent endogenous opioid signaling[1]. |
| References |
| Molecular Formula | C34H31F2N3O3 |
|---|---|
| Molecular Weight | 567.62 |