309711-59-9

309711-59-9 structure

Name: NS383
Chemical Name: NS 383
CAS Number: 309711-59-9
Molecular Formula: C₁₉H₁₉N₃O₂
Molecular Weight: 321.37
Create Date: 2022-03-15 20:03:50
Modify Date: 2024-01-14 12:07:35
NS383 is a potent and uniquely selective inhibitor of rat ASICs containing 1a and/or 3 subunits. NS383 inhibits H(+)-activated currents recorded from rat homomeric ASIC1a, ASIC3, and heteromeric ASIC1a+3 with IC50 values ranging from 0.61 to 2.2 μM. NS383 is well tolerated and capable of reversing pathological painlike behaviors, presumably via peripheral actions, but possibly also via actions within central pain circuits[1].

Name	NS 383
Synonyms	8-Ethyl-6,7,8,9-tetrahydro-5-phenyl-1H-pyrrolo[3,2-h]isoquinoline-2,3-dione-3-oxime 1H-Pyrrolo[3,2-h]isoquinolin-2-ol, 8-ethyl-6,7,8,9-tetrahydro-3-nitroso-5-phenyl- 8-Ethyl-3-nitroso-5-phenyl-6,7,8,9-tetrahydro-1H-pyrrolo[3,2-h]isoquinolin-2-ol

Description	NS383 is a potent and uniquely selective inhibitor of rat ASICs containing 1a and/or 3 subunits. NS383 inhibits H(+)-activated currents recorded from rat homomeric ASIC1a, ASIC3, and heteromeric ASIC1a+3 with IC50 values ranging from 0.61 to 2.2 μM. NS383 is well tolerated and capable of reversing pathological painlike behaviors, presumably via peripheral actions, but possibly also via actions within central pain circuits[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
References	[1]. Munro G, et al. NS383 Selectively Inhibits Acid-Sensing Ion Channels Containing 1a and 3 Subunits to Reverse Inflammatory and Neuropathic Hyperalgesia in Rats. CNS Neurosci Ther. 2016;22(2):135-145.