64544-24-7

64544-24-7 structure

Name: Moclobemide N-Oxide
Chemical Name: Moclobemide N-Oxide
CAS Number: 64544-24-7
Molecular Formula: C₁₃H₁₇ClN₂O₃
Molecular Weight: 284.74
Catalog: Signaling Pathways Neuronal Signaling Monoamine Oxidase
Create Date: 2022-03-26 23:19:21
Modify Date: 2024-01-15 09:54:51
Moclobemide N-Oxide (Ro 12-5637) is N-oxide metabolite of Moclobemide. Moclobemide N-Oxide retains certain MAO-A (monoamine oxidase) inhibitory activity, but is generally present in low concentrations. Moclobemide N-Oxide can be detected by UV absorption at 240 nm[1][2].

Name	Moclobemide N-Oxide
Synonyms	Ro 12-5637 4-Chloro-N-[2-(4-oxido-4-morpholinyl)ethyl]benzamide Benzamide, 4-chloro-N-[2-(4-oxido-4-morpholinyl)ethyl]- 4-Chloro-N-[2-(4-morpholinyl)ethyl]benzamide N-Oxide

Description	Moclobemide N-Oxide (Ro 12-5637) is N-oxide metabolite of Moclobemide. Moclobemide N-Oxide retains certain MAO-A (monoamine oxidase) inhibitory activity, but is generally present in low concentrations. Moclobemide N-Oxide can be detected by UV absorption at 240 nm[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease
Target	MAO-A
References	[1]. Rakic Ignjatovic A, et al. Moclobemide monotherapy vs. combined therapy with valproic acid or carbamazepine in depressive patients: a pharmacokinetic interaction study. Br J Clin Pharmacol. 2009 Feb;67(2):199-208. [2]. Geschke R, et al. Determination of the new monoamine oxidase inhibitor moclobemide and three of its metabolites in biological fluids by high-performance liquid chromatography. J Chromatogr. 1987 Sep 4;420(1):111-20.