2703054-47-9

2703054-47-9 structure

Name: Adenosine receptor antagonist 2
Chemical Name: Adenosine receptor antagonist 2
CAS Number: 2703054-47-9
Molecular Formula: C₂₃H₂₁FN₈O
Molecular Weight: 444.46
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2022-05-23 15:50:22
Modify Date: 2024-01-12 18:28:22
Adenosine receptor antagonist 2 is an orally active A2a/A2b adenosine receptor antagonist with IC50s of 1 nM and 3 nM, respectively. Adenosine receptor antagonist 2 has anti-tumor activity[1].

Name	Adenosine receptor antagonist 2

Description	Adenosine receptor antagonist 2 is an orally active A2a/A2b adenosine receptor antagonist with IC50s of 1 nM and 3 nM, respectively. Adenosine receptor antagonist 2 has anti-tumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	A2a adenosine receptor:1 nM (IC50) A2b adenosine receptor:3 nM (IC50)
In Vivo	Adenosine receptor antagonist 2 (compound L-1; po; 10, 30, 100 mg/kg; twice a day for 22 days) inhibits tumor growth in female C57BL / 6mice mice with MC38(#22)-hpd-L1 cells[1]. Adenosine receptor antagonist 2 (iv; 2 mg/kg) has a CLz of 14.7 mL/min·kg and an AUC of 2252 h·ng/mL. Adenosine receptor antagonist 2 (po; 10 mg/kg) has a Cmax of 8730 ng/mL in adult male ICR mice (weight 25-40g)[1].
References	[1]. Lifeng Liu, et al. Substituted pyrimidine or Pyridylamine derivatives, their compositions and pharmaceutical uses. WO2021185256A1.

Molecular Formula	C₂₃H₂₁FN₈O
Molecular Weight	444.46