2245074-20-6

2245074-20-6 structure

Name: HP1328
Chemical Name: HP1328
CAS Number: 2245074-20-6
Molecular Formula: C₂₃H₂₃N₃O₃
Molecular Weight: 389.45
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FLT3
Create Date: 2022-04-20 20:53:35
Modify Date: 2025-08-27 16:53:47
HP1328 is a potent inhibitor of FLT3 receptor tyrosine kinase (FLT3/ITD mutation). HP1328 is a benzoimidazole scaffold-based compound. HP1328 significantly reduces the leukemia burden and prolongs the survival of mice with FLT3/ITD leukemia[1].

Name	HP1328

Description	HP1328 is a potent inhibitor of FLT3 receptor tyrosine kinase (FLT3/ITD mutation). HP1328 is a benzoimidazole scaffold-based compound. HP1328 significantly reduces the leukemia burden and prolongs the survival of mice with FLT3/ITD leukemia[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3
References	[1]. Tian T, et al. Identification of the Benzoimidazole Compound as a Selective FLT3 Inhibitor by Cell-Based High-Throughput Screening of a Diversity Library. J Med Chem. 2022 Feb 24;65(4):3597-3605.

Molecular Formula	C₂₃H₂₃N₃O₃
Molecular Weight	389.45