2411819-82-2

2411819-82-2 structure

Name: NBD-14270
Chemical Name: NBD-14270
CAS Number: 2411819-82-2
Molecular Formula: C₁₈H₁₈F₃N₅O₂S
Molecular Weight: 425.43
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2022-04-14 19:27:04
Modify Date: 2024-01-10 19:34:54
NBD-14270, a pyridine analogue, is a potent HIV-1 entry antagonist with an IC50 of 180 nM against 50 HIV-1 Env-pseudotyped viruses. NBD-14270 binds to HIV-1 gp120 and shows potent antiviral activity. NBD-14270 shows low cytotoxicity (CC50>100 μM)[1][2].

Name	NBD-14270

Description	NBD-14270, a pyridine analogue, is a potent HIV-1 entry antagonist with an IC50 of 180 nM against 50 HIV-1 Env-pseudotyped viruses. NBD-14270 binds to HIV-1 gp120 and shows potent antiviral activity. NBD-14270 shows low cytotoxicity (CC50>100 μM)[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV-1
In Vitro	NBD-14270 has anti-HIV-1 activity (IC50=0.16 μM ) and Cytotoxicity (CC50=109.3 μM) in single-cycle (TZM-bl Cells) assay[1]. NBD-14270 does not induce toxicity in the U87-CD4-CXCR4 cell line at the doses used for this assay[1].
References	[1]. Francesca Curreli, et al. Preclinical Optimization of gp120 Entry Antagonists as anti-HIV-1 Agents with Improved Cytotoxicity and ADME Properties through Rational Design, Synthesis, and Antiviral Evaluation. J Med Chem. 2020 Feb 27;63(4):1724-1749. [2]. Natalie Losada, et al. HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites. J Med Chem. 2021 Nov 25;64(22):16530-16540.

Molecular Formula	C₁₈H₁₈F₃N₅O₂S
Molecular Weight	425.43