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1466445-39-5

1466445-39-5 structure

1466445-39-5 structure

Name: EGFR-IN-40
Chemical Name: EGFR-IN-40
CAS Number: 1466445-39-5
Molecular Formula: C₂₃H₂₀N₆O₃
Molecular Weight: 428.44
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2022-06-16 20:57:25
Modify Date: 2024-01-20 12:44:13
EGFR-IN-40 (compound 3z) is a potent BTK, EGFR, and ITK inhibitor with IC50 values of 1.2 nM, 5.3 nM, and 46.1 nM, respectively[1].

Name	EGFR-IN-40

Description	EGFR-IN-40 (compound 3z) is a potent BTK, EGFR, and ITK inhibitor with IC50 values of 1.2 nM, 5.3 nM, and 46.1 nM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Itk
Target	EGFR:5.3 nM (IC50) BTK:1.2 nM (IC50) ITK:46.1 nM (IC50)
References	[1]. Dou Dou, et al. Discovery of Pteridine-7(8 H)-one Derivatives as Potent and Selective Inhibitors of Bruton's Tyrosine Kinase (BTK). J Med Chem. 2022 Feb 10;65(3):2694-2709.

Molecular Formula	C₂₃H₂₀N₆O₃
Molecular Weight	428.44

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