2499966-50-4
2499966-50-4 structure
- Name: FLT3-IN-11
- Chemical Name: FLT3-IN-11
- CAS Number: 2499966-50-4
- Molecular Formula: C20H25F3N6O
- Molecular Weight: 422.45
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FLT3
- Create Date: 2022-07-01 11:18:04
- Modify Date: 2024-01-10 19:11:02
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FLT3-IN-11 (compound 30) is a potent, selective and orally active FLT3 kinase inhibitor with IC50s of 7.22 nM and 4.95 nM for wild-type FLT3 and FLT3-D835Y, respectively. FLT3-IN-11 high selectivity for FLT3 over c-KIT (>1000-fold). FLT3-IN-11has excellent anti-acute myeloid leukemia (AML) activity (MV4-11 cells, IC50 of 3.2 nM)[1].
| Name | FLT3-IN-11 |
|---|
| Description | FLT3-IN-11 (compound 30) is a potent, selective and orally active FLT3 kinase inhibitor with IC50s of 7.22 nM and 4.95 nM for wild-type FLT3 and FLT3-D835Y, respectively. FLT3-IN-11 high selectivity for FLT3 over c-KIT (>1000-fold). FLT3-IN-11has excellent anti-acute myeloid leukemia (AML) activity (MV4-11 cells, IC50 of 3.2 nM)[1]. |
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| Related Catalog | |
| Target |
IC50: 7.22 nM (wild-type FLT3) and 4.95 nM (FLT3-D835Y)[1] |
| In Vitro | FLT3-IN-11 (compound 30) efficiently inhibits the growth of multiple mutant BaF3 cells expressing FLT3-ITD, FLT3-D835V/F, FLT3-F691L, FLT3-ITD-F691L, and FLT3-ITD-D835Y[1]. |
| In Vivo | Oral administration of FLT3-IN-11 (compound 30) at 6 mg/kg/d could significantly suppress tumor growth in the MV4-11 cell-inoculated xenograft model, exhibiting tumor growth inhibitory rates of 83.5%[1]. |
| References |
| Molecular Formula | C20H25F3N6O |
|---|---|
| Molecular Weight | 422.45 |