2641054-59-1

2641054-59-1 structure

2641054-59-1 structure

Name: LRRK2-IN-4
Chemical Name: LRRK2-IN-4
CAS Number: 2641054-59-1
Molecular Formula: C₂₅H₂₉ClF₂N₆O₂
Molecular Weight: 518.99
Catalog: Signaling Pathways Autophagy LRRK2
Create Date: 2022-05-22 15:03:14
Modify Date: 2024-01-12 20:18:08
LRRK2-IN-4 is a potent, selective, CNS-penetran and orally active leucine-rich repeat kinase 2 (LRRK2) inhobitor with an IC50 of 2.6 nM. LRRK2-IN-4 has the potential for the research of Parkinson’s disease[1].

Name	LRRK2-IN-4

Description	LRRK2-IN-4 is a potent, selective, CNS-penetran and orally active leucine-rich repeat kinase 2 (LRRK2) inhobitor with an IC50 of 2.6 nM. LRRK2-IN-4 has the potential for the research of Parkinson’s disease[1].
Related Catalog	Signaling Pathways >> Autophagy >> LRRK2 Research Areas >> Neurological Disease
Target	IC50: 2.6 nM (LRRK2)[1]
In Vivo	LRRK2-IN-4 (compound 24) (p.o.) shows good oral bioavailability in male Wistar-Han rats (F=64%), male beagle dogs (F=65%)[1].
References	[1]. Keylor MH, et al. Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors. J Med Chem. 2022; 65(1):838-856.

Molecular Formula	C₂₅H₂₉ClF₂N₆O₂
Molecular Weight	518.99