Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

2641054-59-1

2641054-59-1 structure

2641054-59-1 structure

Name: LRRK2-IN-4
Chemical Name: LRRK2-IN-4
CAS Number: 2641054-59-1
Molecular Formula: C₂₅H₂₉ClF₂N₆O₂
Molecular Weight: 518.99
Catalog: Signaling Pathways Autophagy LRRK2
Create Date: 2022-05-22 15:03:14
Modify Date: 2025-08-27 10:46:47
LRRK2-IN-4 is a potent, selective, CNS-penetran and orally active leucine-rich repeat kinase 2 (LRRK2) inhobitor with an IC50 of 2.6 nM. LRRK2-IN-4 has the potential for the research of Parkinson’s disease[1].

Name	LRRK2-IN-4

Description	LRRK2-IN-4 is a potent, selective, CNS-penetran and orally active leucine-rich repeat kinase 2 (LRRK2) inhobitor with an IC50 of 2.6 nM. LRRK2-IN-4 has the potential for the research of Parkinson’s disease[1].
Related Catalog	Signaling Pathways >> Autophagy >> LRRK2 Research Areas >> Neurological Disease
Target	IC50: 2.6 nM (LRRK2)[1]
In Vivo	LRRK2-IN-4 (compound 24) (p.o.) shows good oral bioavailability in male Wistar-Han rats (F=64%), male beagle dogs (F=65%)[1].
References	[1]. Keylor MH, et al. Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors. J Med Chem. 2022; 65(1):838-856.

Molecular Formula	C₂₅H₂₉ClF₂N₆O₂
Molecular Weight	518.99

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.