1834610-73-9

1834610-73-9 structure

Name: PF-06456384
Chemical Name: PF-06456384
CAS Number: 1834610-73-9
Molecular Formula: C₃₅H₃₂F₃N₇O₃S₂
Molecular Weight: 719.80
Catalog: Signaling Pathways Autophagy LRRK2
Create Date: 2022-05-22 11:33:31
Modify Date: 2025-08-23 18:44:07
PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively. PF-06447475 can be used for parkinson's disease (PD) research[1].

Name	PF-06456384

Description	PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively. PF-06447475 can be used for parkinson's disease (PD) research[1].
Related Catalog	Signaling Pathways >> Autophagy >> LRRK2 Research Areas >> Neurological Disease
References	[1]. Jaclyn L Henderson, et al. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58(1):419-32.

Molecular Formula	C₃₅H₃₂F₃N₇O₃S₂
Molecular Weight	719.80