2750152-64-6

2750152-64-6 structure

2750152-64-6 structure

Name: ATX inhibitor 17
Chemical Name: ATX inhibitor 17
CAS Number: 2750152-64-6
Molecular Formula: C₂₉H₂₉F₅N₈S
Molecular Weight: 616.65
Catalog: Research Areas Cancer
Create Date: 2022-08-10 19:35:17
Modify Date: 2024-01-26 14:03:35
ATX inhibitor 17 is a potent ATX inhibitor with an IC50 of 0.019 µM. ATX inhibitor 17 shows excellent anti-proliferative activities in breast cancer cells[1].

Name	ATX inhibitor 17

Description	ATX inhibitor 17 is a potent ATX inhibitor with an IC50 of 0.019 µM. ATX inhibitor 17 shows excellent anti-proliferative activities in breast cancer cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 0.019 µM (ATX)[1]
In Vitro	ATX inhibitor 17 (compound 25a) (0-15 µM; 72 h) shows excellent anti-proliferative activities in breast cancer cells[1]. Cell Cytotoxicity Assay[1] Cell Line: MCF7, MDA-MB-231, A549, H2228 cells Concentration: 0-15 µM Incubation Time: 72 h Result: Showed excellent antiproliferative effects with IC50s of 1.01, 0.79, 13.40, >15 µM for MCF7, MDA-MB-231, A549, H2228 cells, respectively.
References	[1]. Lei H,et al. Structure guided design of potent indole-based ATX inhibitors bearing hydrazone moiety with tumor suppression effects. Eur J Med Chem. 2020 Sep 1;201:112456.

Molecular Formula	C₂₉H₂₉F₅N₈S
Molecular Weight	616.65