2750152-64-6

2750152-64-6 structure
2750152-64-6 structure
  • Name: ATX inhibitor 17
  • Chemical Name: ATX inhibitor 17
  • CAS Number: 2750152-64-6
  • Molecular Formula: C29H29F5N8S
  • Molecular Weight: 616.65
  • Catalog: Research Areas Cancer
  • Create Date: 2022-08-10 19:35:17
  • Modify Date: 2024-01-26 14:03:35
  • ATX inhibitor 17 is a potent ATX inhibitor with an IC50 of 0.019 µM. ATX inhibitor 17 shows excellent anti-proliferative activities in breast cancer cells[1].

Name ATX inhibitor 17
Description ATX inhibitor 17 is a potent ATX inhibitor with an IC50 of 0.019 µM. ATX inhibitor 17 shows excellent anti-proliferative activities in breast cancer cells[1].
Related Catalog
Target

IC50: 0.019 µM (ATX)[1]

In Vitro ATX inhibitor 17 (compound 25a) (0-15 µM; 72 h) shows excellent anti-proliferative activities in breast cancer cells[1]. Cell Cytotoxicity Assay[1] Cell Line: MCF7, MDA-MB-231, A549, H2228 cells Concentration: 0-15 µM Incubation Time: 72 h Result: Showed excellent antiproliferative effects with IC50s of 1.01, 0.79, 13.40, >15 µM for MCF7, MDA-MB-231, A549, H2228 cells, respectively.
References

[1]. Lei H,et al. Structure guided design of potent indole-based ATX inhibitors bearing hydrazone moiety with tumor suppression effects. Eur J Med Chem. 2020 Sep 1;201:112456.

Molecular Formula C29H29F5N8S
Molecular Weight 616.65
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