2140264-63-5

2140264-63-5 structure
2140264-63-5 structure
  • Name: Clindamycin-13C,d3
  • Chemical Name: Clindamycin-13C,d3
  • CAS Number: 2140264-63-5
  • Molecular Formula: C1713CH30D3ClN2O5S
  • Molecular Weight: 428.99
  • Catalog: Signaling Pathways Anti-infection Bacterial
  • Create Date: 2022-06-09 16:52:48
  • Modify Date: 2024-01-10 21:00:12
  • Clindamycin-13C,d3 is the 13C- and deuterium labeled. Clindamycin is an oral protein synthesis inhibitory agent that has the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla)[1].

Name Clindamycin-13C,d3
Description Clindamycin-13C,d3 is the 13C- and deuterium labeled. Clindamycin is an oral protein synthesis inhibitory agent that has the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla)[1].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[59].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

[2]. Hodille E, et al. Clindamycin suppresses virulence expression in inducible clindamycin-resistant Staphylococcus aureus strains. Ann Clin Microbiol Antimicrob. 2018 Oct 20;17(1):38.

Molecular Formula C1713CH30D3ClN2O5S
Molecular Weight 428.99