1257650-73-9

1257650-73-9 structure

1257650-73-9 structure

Name: Hydrocortisone-d2
Chemical Name: Hydrocortisone-d2
CAS Number: 1257650-73-9
Molecular Formula: C₂₁H₂₈D₂O₅
Molecular Weight: 364.47
Catalog: Signaling Pathways GPCR/G Protein Glucocorticoid Receptor
Create Date: 2022-06-10 18:40:21
Modify Date: 2024-01-15 12:36:30
Hydrocortisone-d2 is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1][2].

Name	Hydrocortisone-d2

Description	Hydrocortisone-d2 is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Förster C, et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586(7):1937-49. [3]. Bellinghausen I, et al. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108(2):242-9. [4]. Chappell D, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007 Nov;107(5):776-84.

Molecular Formula	C₂₁H₂₈D₂O₅
Molecular Weight	364.47