2747917-88-8

2747917-88-8 structure

Name: Methocarbamol-13C,d3
Chemical Name: Methocarbamol-13C,d3
CAS Number: 2747917-88-8
Molecular Formula: C₁₀₁₃CH₁₂D₃NO₅
Molecular Weight: 245.25
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
Create Date: 2022-08-27 18:59:18
Modify Date: 2023-02-12 18:15:37
Methocarbamol-13C,d3 is the 13C- and deuterium labeled. Methocarbamol is an orally active central muscle relaxant and blocks muscular Nav1.4 channel. Methocarbamol reversibly affects voltage dependence of inactivation of Nav1.4 channel. Methocarbamol has the potential for muscle spasms and pain syndromes research[1][2][3].

Name	Methocarbamol-13C,d3

Description	Methocarbamol-13C,d3 is the 13C- and deuterium labeled. Methocarbamol is an orally active central muscle relaxant and blocks muscular Nav1.4 channel. Methocarbamol reversibly affects voltage dependence of inactivation of Nav1.4 channel. Methocarbamol has the potential for muscle spasms and pain syndromes research[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[79].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [2]. Bruce, R.B., L.B. Turnbull, and J.H. Newman, Metabolism of methocarbamol in the rat, dog, and human. J Pharm Sci, 1971. 60(1): p. 104-6. [3]. Sica, D.A., et al., Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals. Eur J Clin Pharmacol, 1990. 39(2): p. 193-4. [4]. Yaxin Zhang, et al. Methocarbamol blocks muscular Na v 1.4 channels and decreases isometric force of mouse muscles. Muscle Nerve. 2020 Oct 11.

Molecular Formula	C₁₀₁₃CH₁₂D₃NO₅
Molecular Weight	245.25