1613383-99-5
1613383-99-5 structure
- Name: SW IV-134
- Chemical Name: SW IV-134
- CAS Number: 1613383-99-5
- Molecular Formula: C51H78N6O6
- Molecular Weight: 871.221
- Create Date: 2022-07-01 09:09:18
- Modify Date: 2023-01-29 19:41:57
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SW IV-134 is a sigma-2/SMAC drug conjugate, chemically linked the sigma-2 ligand SW43 to the Smac mimetic SW IV-52.SW IV-134 slowed tumor growth and improved survival in murine models of pancreatic cancer.SW IV-134 significantly reduced tumor burden and improved overall survival in a mouse xenograft model of ovarian cancer without causing significant adverse effects to normal tissues.SW IV-134 induced degradation of cIAP-1 and cIAP-2 leading to NF-қB activation and TNFα-dependent cell death.
| Name | SW IV-134 |
|---|
| Description | SW IV-134 is a sigma-2/SMAC drug conjugate, chemically linked the sigma-2 ligand SW43 to the Smac mimetic SW IV-52.SW IV-134 slowed tumor growth and improved survival in murine models of pancreatic cancer.SW IV-134 significantly reduced tumor burden and improved overall survival in a mouse xenograft model of ovarian cancer without causing significant adverse effects to normal tissues.SW IV-134 induced degradation of cIAP-1 and cIAP-2 leading to NF-қB activation and TNFα-dependent cell death. |
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| References | 1. Garg G, et al. Mol Cancer. 2014 Mar 7;13:50. 2. Hashim YM, et al. Mol Oncol. 2014 Jul;8(5):956-67. 3. Hashim YM, et al. J Exp Clin Cancer Res. 2017 Jan 17;36(1):14. 4. Oost TK, et al. J Med Chem. 2004;47:4417–4426. |
| Molecular Formula | C51H78N6O6 |
|---|---|
| Molecular Weight | 871.221 |