2484895-50-1
2484895-50-1 structure
- Name: NR-160
- Chemical Name: NR-160
- CAS Number: 2484895-50-1
- Molecular Formula: C25H21F3N6O3
- Molecular Weight: 510.477
- Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
- Create Date: 2022-07-02 21:20:36
- Modify Date: 2024-01-18 15:11:00
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NR-160 (NR160) is a novel potent, selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 30 nM, shows SI (75-1847 )over all HDAC class I isoforms.NR-160 induced α-tubulin acetylation (ac-α-tubulin) in treated acute myeloid leukemic (AML) cell line HL60, but not histone H3 (ac-H3) (a marker for the inhibition of class I HDACs).NR-160 enhances the cytotoxicity induction of bortezomib, epirubicin and daunorubicin on a panel of seven leukemia cell lines
| Name | NR-160 |
|---|
| Description | NR-160 (NR160) is a novel potent, selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 30 nM, shows SI (75-1847 )over all HDAC class I isoforms.NR-160 induced α-tubulin acetylation (ac-α-tubulin) in treated acute myeloid leukemic (AML) cell line HL60, but not histone H3 (ac-H3) (a marker for the inhibition of class I HDACs).NR-160 enhances the cytotoxicity induction of bortezomib, epirubicin and daunorubicin on a panel of seven leukemia cell lines |
|---|---|
| References | 1. Nina Reßing, et al. J Med Chem. 2020 Sep 24;63(18):10339-10351. |
| Molecular Formula | C25H21F3N6O3 |
|---|---|
| Molecular Weight | 510.477 |