2650530-00-8
2650530-00-8 structure
- Name: SGC-STK17B-1
- Chemical Name: SGC-STK17B-1
- CAS Number: 2650530-00-8
- Molecular Formula: C16H10N2O2S3
- Molecular Weight: 358.448
- Catalog: Research Areas Cancer
- Create Date: 2022-07-01 18:22:52
- Modify Date: 2023-01-14 17:37:39
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SGC-STK17B-1 is a potent, selective, ATP-competitive inhibitor of death-associated protein kinase family member STK17B (DRAK2) with IC50 of 34 nM, >100-fold selectivity over STK17A;SGC-STK17B-1 is also >100-fold selective over all of the other kinases tested, with only STK17A, CAMKK1, and AURKB (IC50s=5-9 uM) in panel of 403 wild type human kinase assays.SGC-STK17B-1 demonstrated the highest cell potency in the NanoBRET target engagement assay (IC50=190 nM).SGC-STK17B-1 is the first truly potent and selective chemical probe of STK17B.
| Name | SGC-STK17B-1 |
|---|
| Description | SGC-STK17B-1 is a potent, selective, ATP-competitive inhibitor of death-associated protein kinase family member STK17B (DRAK2) with IC50 of 34 nM, >100-fold selectivity over STK17A;SGC-STK17B-1 is also >100-fold selective over all of the other kinases tested, with only STK17A, CAMKK1, and AURKB (IC50s=5-9 uM) in panel of 403 wild type human kinase assays.SGC-STK17B-1 demonstrated the highest cell potency in the NanoBRET target engagement assay (IC50=190 nM).SGC-STK17B-1 is the first truly potent and selective chemical probe of STK17B. |
|---|---|
| References | 1. Alfredo Picado, et al. J Med Chem. 2020 Dec 10;63(23):14626-14646. |
| Molecular Formula | C16H10N2O2S3 |
|---|---|
| Molecular Weight | 358.448 |