2756323-15-4
2756323-15-4 structure
- Name: MS934
- Chemical Name: MS934
- CAS Number: 2756323-15-4
- Molecular Formula: C52H69F3In7O6S
- Molecular Weight: 1104.127
- Catalog: Signaling Pathways MAPK/ERK Pathway MEK
- Create Date: 2022-07-11 23:58:33
- Modify Date: 2024-01-06 11:47:51
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MS934 (MS-934) is a VHL-recruiting MEK1/2 degrader (PROTAC) with HT29 DC50 of 18/9 nM for MEK1/2 degradation, respectively.MS934 displays antiproliferation potency against HT29 cell with GI50 of 23 nM, degrades MEK1 and MEK2 and inhibits pMEK and pERK in a concentration-dependent manner in HT-29 and SK-MEL-28 cells.
| Name | MS934 |
|---|
| Description | MS934 (MS-934) is a VHL-recruiting MEK1/2 degrader (PROTAC) with HT29 DC50 of 18/9 nM for MEK1/2 degradation, respectively.MS934 displays antiproliferation potency against HT29 cell with GI50 of 23 nM, degrades MEK1 and MEK2 and inhibits pMEK and pERK in a concentration-dependent manner in HT-29 and SK-MEL-28 cells. |
|---|---|
| References | 1. Jianping Hu, et al. J Med Chem. 2020 Dec 24;63(24):15883-15905. |
| Molecular Formula | C52H69F3In7O6S |
|---|---|
| Molecular Weight | 1104.127 |