2102170-43-2
2102170-43-2 structure
- Name: GNE-2256
- Chemical Name: GNE-2256
- CAS Number: 2102170-43-2
- Molecular Formula: C24H27FN6O4
- Molecular Weight: 482.516
- Catalog: Signaling Pathways Immunology/Inflammation IRAK
- Create Date: 2022-07-02 10:38:00
- Modify Date: 2024-01-19 18:17:59
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GNE-2256 (GNE2256) is a potent, selective inhibitor of IRAK4 with biochemical Ki of 1.4 nM.GNE-2256 displays high selectivity in the CEREP panel with off-targets with >50% inhibition are TACR1, HTR2B and ACHE.GNE-2256 is potent in the NanoBRET assay (IC50 = 3.3 nM), the IL-6 human whole blood assay (IC50=190 nM) and the IFNα human whole blood assay (IC50=290 nM).
| Name | GNE-2256 |
|---|
| Description | GNE-2256 (GNE2256) is a potent, selective inhibitor of IRAK4 with biochemical Ki of 1.4 nM.GNE-2256 displays high selectivity in the CEREP panel with off-targets with >50% inhibition are TACR1, HTR2B and ACHE.GNE-2256 is potent in the NanoBRET assay (IC50 = 3.3 nM), the IL-6 human whole blood assay (IC50=190 nM) and the IFNα human whole blood assay (IC50=290 nM). |
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| Molecular Formula | C24H27FN6O4 |
|---|---|
| Molecular Weight | 482.516 |