2490544-50-6
2490544-50-6 structure
- Name: TG8-260
- Chemical Name: TG8-260
- CAS Number: 2490544-50-6
- Molecular Formula: C21H20N4O
- Molecular Weight: 344.418
- Create Date: 2022-07-01 17:20:26
- Modify Date: 2025-08-26 19:36:06
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TG8-260 is a second-generation, potent, selective EP2 antagonist with Schild KB of 13.2 nM.TG8-260 displays 500-fold selectivity to EP2 against other prostanoid receptors.TG8-260 has a plasma half-life of 2.14 h (PO) and excellent oral bioavailability (77.3%), TG8-260 is a potent inhibitor of CYP450 enzymes.TG8-260 displays antagonistic activity on the induction of EP2 receptor-mediated inflammatory gene expression in microglia BV2-hEP2 cells.TG8-260 reduces hippocampal neuroinflammation and gliosis after pilocarpine-induced status epilepticus in rats.TG8-260 is a tool for investigating anti-inflammatory pathways in peripheral inflammatory disease animal models.
| Name | TG8-260 |
|---|
| Description | TG8-260 is a second-generation, potent, selective EP2 antagonist with Schild KB of 13.2 nM.TG8-260 displays 500-fold selectivity to EP2 against other prostanoid receptors.TG8-260 has a plasma half-life of 2.14 h (PO) and excellent oral bioavailability (77.3%), TG8-260 is a potent inhibitor of CYP450 enzymes.TG8-260 displays antagonistic activity on the induction of EP2 receptor-mediated inflammatory gene expression in microglia BV2-hEP2 cells.TG8-260 reduces hippocampal neuroinflammation and gliosis after pilocarpine-induced status epilepticus in rats.TG8-260 is a tool for investigating anti-inflammatory pathways in peripheral inflammatory disease animal models. |
|---|---|
| References | 1. Radhika Amaradhi, et al. ACS Pharmacol Transl Sci. 2022 Jan 25;5(2):118-133. |
| Molecular Formula | C21H20N4O |
|---|---|
| Molecular Weight | 344.418 |