2408695-41-8

2408695-41-8 structure

Name: Antibacterial agent 98
Chemical Name: Antibacterial agent 98
CAS Number: 2408695-41-8
Molecular Formula: C₁₇H₁₃N₅O₃S₂
Molecular Weight: 399.45
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-07-27 06:33:17
Modify Date: 2024-01-12 10:55:47
Antibacterial agent 98 (compound g37) is a potent and orally active antibacterial agent. Antibacterial agent 98 inhibits the ATPase activity of Gyrase B and impairs Staphylococcus aureus (S. aureus ) DNA supercoiling. Antibacterial agent 98 shows antibacterial activity and not induce resistance development of MRSA (methicillin-resistant S. aureus)[1].

Name	Antibacterial agent 98

Description	Antibacterial agent 98 (compound g37) is a potent and orally active antibacterial agent. Antibacterial agent 98 inhibits the ATPase activity of Gyrase B and impairs Staphylococcus aureus (S. aureus ) DNA supercoiling. Antibacterial agent 98 shows antibacterial activity and not induce resistance development of MRSA (methicillin-resistant S. aureus)[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Antibacterial agent 98 (compound g37) shows antibacterial activity with an NICs of 0.1 μg/mL for S. aureus ATCC29213 and an IC50 of 0.15 µM for GyrB[1]. Antibacterial agent 98 shows cytotoxicity with IC50s of 55.3, 38.8 µM for HepG2, HUVEC cells, respectively[1].
References	[1]. Xue W, et al. N-thiadiazole-4-hydroxy-2-quinolone-3-carboxamides bearing heteroaromatic rings as novel antibacterial agents: Design, synthesis, biological evaluation and target identification. Eur J Med Chem. 2020 Feb 15;188:112022.

Molecular Formula	C₁₇H₁₃N₅O₃S₂
Molecular Weight	399.45